From sub-atomic to astronomical scales, we are working on the frontiers of science. Founded by Nobel laureates and members of the National Academy of Sciences, our departments have all played a central role in UC San Diego’s rapid rise to national and international prominence.
A tradition of bridging boundaries long before interdisciplinary research became fashionable has allowed us to probe fundamental questions at the intersections different branches of science and mathematics and to create new fields of study. Because mathematics and the physical sciences are fundamental to many pursuits, including engineering, medicine and biology, we contribute to the education of most undergraduate students at UC San Diego.
Elizabeth Villa, who is helping to develop a new kind of telescope, and Ryan Anderson, nanofabrication engineer
Elizabeth Villa, a new assistant professor in the Department of Chemistry and Biochemistry, along with her colleagues at Germany’s Max Planck Institute of Biochemistry, adapted a focused-ion-beam microscope for biological applications during her postdoctoral studies. The design was adopted by the Dutch company FEI into a first-of-a-kind prototype that Villa will further develop at UC San Diego in collaboration with the company.
“With cryo-electron tomography techniques, we can create 3D pictures of the cells called tomograms,” Villa says. “What I do is exactly equivalent to a CT (computed tomography) scan, except the cells are a million times smaller."
Villa adds that another benefit of cryo-electron microscopy is the ability to infer cellular dynamics over time, “or what we call in physics ‘ergodicity.’ I can look at 3,000 nuclear pores frozen at different times to infer the cellular dynamics, classify all of this information and then make predictions. We can then do a light microscopy experiment in vivo and correlate what we see with the previous data we’ve gathered.” Read more.
Our immune system copes with a multitude of threats using a mix-and-match system to create millions of different antibodies.
The white blood cells that produce these antibodies assemble their specific versions by selecting three gene segments from among multiple variants.
Joseph Lucas, a graduate student working with Cornelis Murre, a professor of biology at UC San Diego, tagged individual gene segments in live cells to track their movement in three dimensions.
To better understand what they observed, the biologists turned to Yaojun Zhang, a graduate student in physics and her advisor, Olga Dudko, a professor of physics at UC San Diego, who analyzed the movements. They recognized the patterns as ‘fractional Langevin motion.’
Robina Shaheen measured sulfur isotopes from snow.
Sulfur signals in the Antarctic snow have revealed the importance of overlooked atmospheric chemistry for understanding climate, past and future.
Eruptions of huge volcanoes, the disruptive weather pattern known as El Niño, and a fire season from hell each left distinctive chemical marks in layers of snow excavated near the South Pole, researchers from the University of California, San Diego and France report in the Proceedings of the National Academy of Sciences the week of August 4.
Sorting out the chemical reactions that must have led to those traces revealed a process, known but overlooked, that should be included in models of climate, both forecasts of climate to come and those built to understand Earth’s early history.
“We observed huge signals from ENSO driven changes like extreme dry weather and ensuing biomass burning, which surprised me,” said Robina Shaheen, a project scientist in chemistry at UC San Diego and lead author of the report. “The pattern we saw fits signals that have been observed in pre-Cambrian rocks, which prompted us to take another look at which molecules play a role in this chemistry.” Read more.
An elusive state of matter called superconductivity could be realized in stacks of sheetlike crystals just a few atoms thick, a trio of physicists has determined.
Superconductivity, the flow of electrical current without resistance, is usually found in materials chilled to the most frigid temperatures, which is impractical for most applications. It's been observed at higher temperatures–higher being about 100 kelvin or minus 280 degrees below zero Fahrenheit–in copper oxide materials called cuprate superconductors. But those materials are brittle and unsuitable for fabricating devices like circuits.
In a paper published in Nature Communications, Michael Fogler and Leonid Butov, professors of physics at the University of California, San Diego, and Konstantin Novoselov, Nobel laureate in physics and professor at the University of Manchester, propose a design for an artificially structured material that should support superconductivity at temperatures rivaling those seen for cuprates. Read more.Image: JACS
Long chains of sugars dangle from proteins on the surface of embryonic stem cells and play an important role in how the cells develop into specific cell types. Kamil Godula, an assistant professor of chemistry and biochemistry, and his research group have now synthesized a molecular mimic of these sugar-decorated proteins that helps direct mouse embryonic stem cells down the path toward nerve cells they report in the Journal of the American Chemical Society. The researchers hope others can easily adopt their method to explore how these cell surface sugars influence stem cell differentiation. Read more about these molecular mimics in Chemical and Engineering News.